Article
Differential mutation patterns in thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 clones passaged in the presence of acyclovir or penciclovir.
Antimicrobial agents and chemotherapy - 1 May 2003
Suzutani Tatsuo, Ishioka Ken, De Clercq Erik, Ishibashi Kei, Kaneko Hisatoshi, Kira Toshihiko, Hashimoto Koh-Ichi, Ogasawara Masahiro, Ohtani Katsuki, Wakamiya Nobutaka, Saijo Masayuki
Abstract excerpt
A total of 21 clones of acyclovir (ACV)-resistant (ACV(r)) herpes simplex virus type 1 (HSV-1) and 23 clones of penciclovir (PCV)-resistant (PCV(r)) HSV-1, emerging during serial passages in the presence of ACV or PCV, were isolated under conditions excluding contamination of resistant mutants in the starting virus culture, and their mutations in the thymidine kinase (TK) and DNA polymerase (DNA Pol) genes were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.