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Article

Relevance of non-synonymous thymidine kinase mutations for antiviral resistance of recombinant herpes simplex virus type 2 strains.

Antiviral research - 1 Apr 2018

Brunnemann Anne-Kathrin, Hoffmann Anja, Deinhardt-Emmer Stefanie, Nagel Claus-Henning, Rose Ruben, Fickenscher Helmut, Sauerbrei Andreas, Krumbholz Andi

Abstract excerpt

Therapy or prophylaxis of herpes simplex virus type 2 (HSV-2) infections with the nucleoside analog aciclovir (ACV) can lead to the emergence of drug-resistant HSV-2 strains, particularly in immunocompromised patients. In this context, multiple amino acid (aa) changes can accumulate in the ACV-converting viral thymidine kinase (TK) which hampers sequence-based diagnostics significantly. In this study, the so far...

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PMID: 29427675
DOI: 10.1016/j.antiviral.2018.02.004

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CPE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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