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Article

Phenotypic and genotypic characterization of induced acyclovir-resistant clinical isolates of herpes simplex virus type 1.

Antiviral research - 1 Nov 2013

Hussin Ainulkhir, Md Nor Norefrina Shafinaz, Ibrahim Nazlina

Abstract excerpt

Eleven strains of acyclovir (ACV)-resistant herpes simplex virus type 1 (HSV-1) were generated from HSV-1 clinical isolates by exposure to ACV. Genotype of the thymidine kinase (TK) and DNA polymerase (pol) genes from these mutants were further analyzed. Genotypic analysis revealed four non-synonymous mutations in TK gene associated with gene polymorphism and two to three non-synonymous mutations in DNA pol gene....

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Identifiers

PMID: 24055837
DOI: 10.1016/j.antiviral.2013.09.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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