MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition

Abstract excerpt

Genetic alterations of the mixed-lineage leukemia (MLL) gene are commonly implicated in the development of acute leukemias. In acute myeloid leukemia (AML) a partial tandem duplication (PTD) of MLL occurs in about 5%–11%1–4 of patients and has been linked to poor treatment outcome.1,5 Although recent studies show that MLL-PTD does not have a prognostic impact in CN-AML patients treated with intensive therapy,2,3...