Article
The Mll partial tandem duplication: differential, tissue-specific activity in the presence or absence of the wild-type allele.
Blood - 15 Sept 2008
Dorrance Adrienne M, Liu Shujun, Chong Anita, Pulley Benjamin, Nemer David, Guimond Martin, Yuan Weifeng, Chang Dennis, Whitman Susan P, Marcucci Guido, Caligiuri Michael A
Abstract excerpt
The partial tandem duplication of MLL (MLL-PTD) is found in 5% to 10% of patients with acute myeloid leukemia (AML) and normal cytogenetics. Its expression in leukemic blasts is coincident with a silenced wild-type (WT) MLL allele. We therefore generated mice expressing the Mll-PTD in the absence of Mll-WT. These Mll(PTD/-) mice die at birth unlike the normal life expectancy of Mll(PTD/WT), Mll(WT/-), and...
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