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Article

Neurospora WC-1 recruits SWI/SNF to remodel frequency and initiate a circadian cycle.

PLoS genetics - 1 Sept 2014

Wang Bin, Kettenbach Arminja N, Gerber Scott A, Loros Jennifer J, Dunlap Jay C

Abstract excerpt

In the negative feedback loop comprising the Neurospora circadian oscillator, the White Collar Complex (WCC) formed from White Collar-1 (WC-1) and White Collar-2 (WC-2) drives transcription of the circadian pacemaker gene frequency (frq). Although FRQ-dependent repression of WCC has been extensively studied, the mechanism by which the WCC initiates a circadian cycle remains elusive. Structure/function analysis of...

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Identifiers

PMID: 25254987
DOI: 10.1371/journal.pgen.1004599
PMCID: PMC4177678

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Neurospora WC-1 recruits SWI/SNF to remodel frequency and initiate a circadian cycle.PMID 25254987Read ↗

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Execution of the circadian negative feedback loop in Neurospora requires the ATP-dependent chromatin-remodeling enzyme CLOCKSWITCH.Semantic proximity Read ↗

PAS domain-mediated WC-1/WC-2 interaction is essential for maintaining the steady-state level of WC-1 and the function of both proteins in circadian clock and light responses of Neurospora.Semantic proximity Read ↗

Transcriptional repression of frequency by the IEC-1-INO80 complex is required for normal Neurospora circadian clock function.Semantic proximity Read ↗

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FRQ-interacting RNA helicase mediates negative and positive feedback in the Neurospora circadian clock.Semantic proximity Read ↗

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