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Article

Transcriptional repression of frequency by the IEC-1-INO80 complex is required for normal Neurospora circadian clock function.

PLoS genetics - 1 Apr 2017

Gai Kexin, Cao Xuemei, Dong Qing, Ding Zhaolan, Wei Yashang, Liu Yingchun, Liu Xiao, He Qun

Abstract excerpt

Rhythmic activation and repression of the frequency (frq) gene are essential for normal function of the Neurospora circadian clock. WHITE COLLAR (WC) complex, the positive element of the Neurospora circadian system, is responsible for stimulation of frq transcription. We report that a C2H2 finger domain-containing protein IEC-1 and its associated chromatin remodeling complex INO80 play important roles in normal...

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Source

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Identifiers

PMID: 28403234
DOI: 10.1371/journal.pgen.1006732
PMCID: PMC5406019

Genes

INO80

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transcriptional repression of frequency by the IEC-1-INO80 complex is required for normal Neurospora circadian clock function.PMID 28403234Read ↗

Neurospora WC-1 recruits SWI/SNF to remodel frequency and initiate a circadian cycle.Semantic proximity Read ↗

Execution of the circadian negative feedback loop in Neurospora requires the ATP-dependent chromatin-remodeling enzyme CLOCKSWITCH.Semantic proximity Read ↗

CKI and CKII mediate the FREQUENCY-dependent phosphorylation of the WHITE COLLAR complex to close the Neurospora circadian negative feedback loop.Semantic proximity Read ↗

Phosphorylation of FREQUENCY protein by casein kinase II is necessary for the function of the Neurospora circadian clock.Semantic proximity Read ↗

Domains required for the interaction of the central negative element FRQ with its transcriptional activator WCC within the core circadian clock of Neurospora.Semantic proximity Read ↗

Light-independent phosphorylation of WHITE COLLAR-1 regulates its function in the Neurospora circadian negative feedback loop.Semantic proximity Read ↗

PAS domain-mediated WC-1/WC-2 interaction is essential for maintaining the steady-state level of WC-1 and the function of both proteins in circadian clock and light responses of Neurospora.Semantic proximity Read ↗

CHD1 remodels chromatin and influences transient DNA methylation at the clock gene frequency.Semantic proximity Read ↗

FRQ-interacting RNA helicase mediates negative and positive feedback in the Neurospora circadian clock.Semantic proximity Read ↗

Roles for WHITE COLLAR-1 in circadian and general photoperception in Neurospora crassa.Semantic proximity Read ↗

Circadian regulation of the light input pathway in Neurospora crassa.Semantic proximity Read ↗

Temperature-sensitive and circadian oscillators of Neurospora crassa share components.Semantic proximity Read ↗

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