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Article

A Dual Role of Heme Oxygenase-1 in Cancer Cells

21 Dec 2018

Abstract excerpt

Heme oxygenase (HO)-1 is known to metabolize heme into biliverdin/bilirubin, carbon monoxide, and ferrous iron, and it has been suggested to demonstrate cytoprotective effects against various stress-related conditions. HO-1 is commonly regarded as a survival molecule, exerting an important role in cancer progression and its inhibition is considered beneficial in a number of cancers. However, increasing studies...

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PMID: 30583467
DOI: 10.3390/ijms20010039

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