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Article

Divergent cardiopulmonary actions of heme oxygenase enzymatic products in chronic hypoxia.

PloS one - 19 Jun 2009

Vitali Sally H, Mitsialis S Alex, Liang Olin D, Liu Xiaoli, Fernandez-Gonzalez Angeles, Christou Helen, Wu Xinqi, McGowan Francis X, Kourembanas Stella

Abstract excerpt

BACKGROUND: Hypoxia and pressure-overload induce heme oxygenase-1 (HO-1) in cardiomyocytes and vascular smooth muscle cells (VSMCs). HO-1(-/-) mice exposed to chronic hypoxia develop pulmonary arterial hypertension (PAH) with exaggerated right ventricular (RV) injury consisting of dilation, fibrosis, and mural thrombi. Our objective was to identify the HO-1 product(s) mediating RV protection from hypoxic injury...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19543386
DOI: 10.1371/journal.pone.0005978
PMCID: PMC2694354

Genes

PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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