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Article

The Role of Heme Oxygenase-1 Promoter Polymorphisms in Perinatal Disease.

International journal of environmental research and public health - 29 Mar 2021

Nakasone Ruka, Ashina Mariko, Abe Shinya, Tanimura Kenji, Van Rostenberghe Hans, Fujioka Kazumichi

Abstract excerpt

Heme oxygenase (HO) is the rate-limiting enzyme in the heme catabolic pathway, which degrades heme into equimolar amounts of carbon monoxide, free iron, and biliverdin. Its inducible isoform, HO-1, has multiple protective functions, including immune modulation and pregnancy maintenance, showing dynamic alteration during perinatal periods. As its contribution to the development of perinatal complications is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33805292
DOI: 10.3390/ijerph18073520
PMCID: PMC8037596

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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