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Article

Detection of human leukemia cells with multidrug-resistance phenotype using multilabeling with fluorescent dyes.

Anticancer research - 1 Jan 2000

Lautier D, Lahmy S, Canitrot Y, Vigo J, Viallet P, Salmon J M

Abstract excerpt

Reduced accumulation of multiple drugs is a characteristic of cells overexpressing P-glycoprotein. This phenotype is referred to as multidrug-resistance (MDR). A protocol based on reduced accumulation of fluorescent dyes is proposed for discriminating MDR cells in cell populations. The combination of three fluorescent dyes, Hoechst 33342, rhodamine 123 and Nile red, with different intracellular targets, has been...

Topics

Antineoplastic Agents
Benzimidazoles
Doxorubicin
Drug Resistance
Fluorescent Dyes
Humans
Leukemia, Lymphoid
Oxazines
Phenotype
Rhodamine 123
Rhodamines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

Verapamil

Vinblastine

Source

Identifiers

PMID: 8239535

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8239535-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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