Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Kinetic analysis of rhodamines efflux mediated by the multidrug resistance protein (MRP1).

Biophysical journal - 1 Sept 2003

Saengkhae Chantarawan, Loetchutinat Chatchanok, Garnier-Suillerot Arlette

Abstract excerpt

Characterization of rhodamine 123 as functional assay for MDR has been primarily focused on P-glycoprotein-mediated MDR. Several studies have suggested that Rh123 is also a substrate for MRP1. However, no quantitative studies of the MRP1-mediated efflux of rhodamines have, up to now, been performed. Measurement of the kinetic characteristics of substrate transport is a powerful approach to enhancing our...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biophysical Phenomena
Share to Biophysics
Share to Chlorine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Daunorubicin

Share to Glutathione

Share to Multidrug Resistance-Associated Proteins

Share to Rhodamine 123

Share to Rhodamines

Source

Open in PubMed Open full text

Identifiers

PMID: 12944313
DOI: 10.1016/S0006-3495(03)74628-1
PMCID: PMC1303372

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Kinetic analysis of rhodamines efflux mediated by the multidrug resistance protein (MRP1).PMID 12944313Read ↗

A comparison of rhodamine 123 accumulation and efflux in cells with P-glycoprotein-mediated and MRP-associated multidrug resistance phenotypes.Semantic proximity Read ↗

Methanethiosulfonate derivatives of rhodamine and verapamil activate human P-glycoprotein at different sites.Semantic proximity Read ↗

In vitro models to evaluate multidrug resistance in cancer cells: Biochemical and morphological techniques and pharmacological strategiesSemantic proximity Read ↗

MDR1 haplotypes significantly minimize intracellular uptake and transcellular P-gp substrate transport in recombinant LLC-PK1 cells.Semantic proximity Read ↗

Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein.Semantic proximity Read ↗

Contrasting features of MDR phenotype in leukemias by using two fluorochromes: implications for clinical practice.Semantic proximity Read ↗

Flow cytometry-based approach to ABCG2 function suggests that the transporter differentially handles the influx and efflux of drugs.Semantic proximity Read ↗

[Quantitative analysis of multidrug resistance phenotype in hematological malignancies].Semantic proximity Read ↗

Comparison of the kinetics of active efflux of 99mTc-MIBI in cells with P-glycoprotein-mediated and multidrug-resistance protein-associated multidrug-resistance phenotypes.Semantic proximity Read ↗

MDR1 polymorphisms G2677T in exon 21 and C3435T in exon 26 fail to affect rhodamine 123 efflux in peripheral blood lymphocytesSemantic proximity Read ↗

Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.Semantic proximity Read ↗

Multi-drug resistance (MDR) activity in acute leukemia determined by rhodamine 123 efflux assay.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.