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Article

Testing the importance of p27 degradation by the SCF <sup>skp2</sup> pathway in murine models of lung and colon cancer

11 Sept 2006

Abstract excerpt

Decreased expression of the CDK inhibitor p27kip1 in human tumors directly correlates with increased resistance to chemotherapies, increased rates of metastasis, and an overall increased rate of patient mortality. It is thought that decreased p27 expression in tumors is caused by increased proteasomal turnover, in particular activation of the pathway governed by the SCFskp2 E3 ubiquitin protein ligase. We have...

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PMID: 16966613
DOI: 10.1073/pnas.0606316103

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Testing the importance of p27 degradation by the SCF <sup>skp2</sup> pathway in murine models of lung and colon cancerPMID 16966613Read ↗

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