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Article

Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice.

Nature genetics - 1 Jan 2010

Wang Hongbo, Bauzon Frederick, Ji Peng, Xu Xiaoliang, Sun Daqian, Locker Joseph, Sellers Rani S, Nakayama Keiko, Nakayama Keiich I, Cobrinik David, Zhu Liang

Abstract excerpt

Heterozygosity of the retinoblastoma gene Rb1 elicits tumorigenesis in susceptible tissues following spontaneous loss of the remaining functional allele. Inactivation of previously studied retinoblastoma protein (pRb) targets partially inhibited tumorigenesis in Rb1(+/-) mice. Here we report that inactivation of pRb target Skp2 (refs. 7,8) completely prevents spontaneous tumorigenesis in Rb1(+/-) mice. Targeted...

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Identifiers

PMID: 19966802
DOI: 10.1038/ng.498
PMCID: PMC2990528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice.PMID 19966802Read ↗

Racing to block tumorigenesis after pRb loss: an innocuous point mutation wins with synthetic lethality.Semantic proximity Read ↗

Targeted Inhibition of the E3 Ligase SCFSkp2/Cks1 Has Antitumor Activity in RB1 -Deficient Human and Mouse Small-Cell Lung CancerSemantic proximity Read ↗

Skp2 is necessary for Myc-induced keratinocyte proliferation but dispensable for Myc oncogenic activity in the oral epithelium.Semantic proximity Read ↗

An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant.Semantic proximity Read ↗

Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase.Semantic proximity Read ↗

Activation of retinoblastoma protein in mammary gland leads to ductal growth suppression, precocious differentiation, and adenocarcinoma.Semantic proximity Read ↗

Targeted inhibition of SCFSKP2 confers anti-tumor activities resulting in a survival benefit in osteosarcomaSemantic proximity Read ↗

The interaction of SKP2 with p27 enhances the progression and stemness of osteosarcomaSemantic proximity Read ↗

Targeted inhibition of SCF <sup>SKP2</sup> confers anti-tumor activities resulting in a survival benefit in osteosarcomaSemantic proximity Read ↗

A Skp2 autoinduction loop and restriction point controlSemantic proximity Read ↗

Role of the F-box protein Skp2 in lymphomagenesisSemantic proximity Read ↗

Skp2 regulates G2/M progression in a p53-dependent manner.Semantic proximity Read ↗

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