Reduced expression of the cell cycle inhibitor p27Kip1 in non-small cell lung carcinoma: a prognostic factor independent of Ras.

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Article

Reduced expression of the cell cycle inhibitor p27Kip1 in non-small cell lung carcinoma: a prognostic factor independent of Ras.

Cancer research - 1 Feb 1999

Catzavelos C, Tsao M S, DeBoer G, Bhattacharya N, Shepherd F A, Slingerland J M

Abstract excerpt

Levels of p27 have been found to have independent prognostic significance in a variety of tumors including breast, colon, prostate, ovary, and gastric carcinomas. We investigated p27 levels and determined ras mutational status in 136 non-small cell lung cancers. We found reduced levels of p27 in...

Topics

Carcinoma, Non-Small-Cell Lung
Cell Cycle
Cell Cycle Proteins
Cyclin-Dependent Kinase Inhibitor p27
Genes, ras
Humans
Lung Neoplasms
Microtubule-Associated Proteins
Mutation
Neoplasm Staging
Prognosis
Tumor Suppressor Proteins

Source

Open in PubMed

Identifiers

PMID: 9973218

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9973218-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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