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Article

A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors.

Genes & development - 15 Nov 2008

Miranda-Carboni Gustavo A, Krum Susan A, Yee Kathleen, Nava Miguel, Deng Qiming E, Pervin Shehla, Collado-Hidalgo Alicia, Galic Zoran, Zack Jerome A, Nakayama Keiko, Nakayama Keiichi I, Lane Timothy F

Abstract excerpt

Loss of the CDK inhibitor p27(KIP1) is widely linked with poor prognosis in human cancer. In Wnt10b-expressing mammary tumors, levels of p27(KIP1) were extremely low; conversely, Wnt10b-null mammary cells expressed high levels of this protein, suggesting Wnt-dependent regulation of p27(KIP1). Interestingly we found that Wnt-induced turnover of p27(KIP1) was independent from classical SCF(SKP2)-mediated...

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Source

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Identifiers

PMID: 19056892
DOI: 10.1101/gad.1692808
PMCID: PMC2593606

Genes

SKP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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