Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The interaction of SKP2 with p27 enhances the progression and stemness of osteosarcoma

16 Feb 2021

Abstract excerpt

Abstract Osteosarcoma is a highly aggressive malignancy for which treatment has remained essentially unchanged for years. Our previous studies found that the F‐box protein SKP2 is overexpressed in osteosarcoma, acting as a proto‐oncogene; p27Kip1 (p27) is an inhibitor of cyclin‐dependent kinases and a downstream substrate of SKP2‐mediated ubiquitination. Overexpression of SKP2 and underexpression of p27 are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Sarcoma Diagnosis and Treatment
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33594717
DOI: 10.1111/nyas.14578

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The interaction of SKP2 with p27 enhances the progression and stemness of osteosarcomaPMID 33594717Read ↗

Targeted inhibition of SCFSKP2 confers anti-tumor activities resulting in a survival benefit in osteosarcomaSemantic proximity Read ↗

Targeted inhibition of SCF <sup>SKP2</sup> confers anti-tumor activities resulting in a survival benefit in osteosarcomaSemantic proximity Read ↗

Comprehensive single cell transcriptomics analysis of murine osteosarcoma uncovers <i>Skp2</i> function in metastasis, genomic instability and immune activation and reveals additional target pathwaysSemantic proximity Read ↗

SKP2 Knockout in Rb1/p53–Deficient Mouse Models of Osteosarcoma Induces Immune Infiltration and Drives a Transcriptional Program with a Favorable PrognosisSemantic proximity Read ↗

SKP2 knockout in Rb1/p53 deficient mouse models of osteosarcoma induces immune infiltration and drives a transcriptional program with a favorable prognosisSemantic proximity Read ↗

A murine mesenchymal stem cell model for initiating events in osteosarcomagenesis points to CDK4/CDK6 inhibition as a therapeutic targetSemantic proximity Read ↗

Skp2 is oncogenic and overexpressed in human cancersSemantic proximity Read ↗

Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice.Semantic proximity Read ↗

WWOX promotes osteosarcoma development via upregulation of MycSemantic proximity Read ↗

Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in OsteosarcomaSemantic proximity Read ↗

Regulation of Skp2 Expression and Activity and Its Role in Cancer ProgressionSemantic proximity Read ↗

Role of the F-box protein Skp2 in lymphomagenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.