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Article

Skp2 is oncogenic and overexpressed in human cancers

17 Apr 2001

Abstract excerpt

Skp2 is a member of the F-box family of substrate-recognition subunits of SCF ubiquitin-protein ligase complexes that has been implicated in the ubiquitin-mediated degradation of several key regulators of mammalian G(1) progression, including the cyclin-dependent kinase inhibitor p27, a dosage-dependent tumor suppressor protein. In this study, we examined Skp2 and p27 protein expression by immunohistochemistry in...

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PMID: 11309491
DOI: 10.1073/pnas.081474898

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