Article
Regulation of the Cdk inhibitor p27 and its deregulation in cancer
2000-04-01
Abstract excerpt
p27 is a cell cycle inhibitor whose cellular abundance increases in response to many antimitogenic stimuli. In this review, we summarize the current knowledge on p27 function and its regulation by synthesis and by ubiquitin-mediated degradation. Importantly, p27 degradation is enhanced in many aggressive human tumors. The frequency with which this is observed suggests that loss of p27 may confer a growth advantage...
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Identifiers and source
- Literature Corpus work
- c8b3a054-8d21-5be0-9920-0865f8d61f2a
- DOI
- 10.1002/(sici)1097-4652(200004)183:1<10::aid-jcp2>3.3.co;2-9