Article
Effect of charge substitutions at residue his-142 on voltage gating of connexin43 channels.
Biophysical journal - 1 Dec 2006
Shibayama Junko, Gutiérrez Cristina, González Daniel, Kieken Fabien, Seki Akiko, Carrión Jesus Requena, Sorgen Paul L, Taffet Steven M, Barrio Luis C, Delmar Mario
Abstract excerpt
Previous studies indicate that the carboxyl terminal of connexin43 (Cx43CT) is involved in fast transjunctional voltage gating. Separate studies support the notion of an intramolecular association between Cx43CT and a region of the cytoplasmic loop (amino acids 119-144; referred to as "L2"). Structural analysis of L2 shows two alpha-helical domains, each with a histidine residue in its sequence (H126 and H142)....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.