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Article

Modifications in the biophysical properties of connexin43 channels by a peptide of the cytoplasmic loop region.

Circulation research - 20 Aug 2004

Seki Akiko, Duffy Heather S, Coombs Wanda, Spray David C, Taffet Steven M, Delmar Mario

Abstract excerpt

Connexin43 (Cx43) channels reside in at least 3 states: closed, open, or residual. It is hypothesized that the residual state results from the interaction of an intracellular "gating element" with structures at the vestibule of the pore. Recently, we showed in vitro that there is an intramolecular interaction of the carboxyl-terminal domain (referred to as "CT") with a region in the cytoplasmic loop of Cx43...

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Identifiers

PMID: 15284189
DOI: 10.1161/01.RES.0000140737.62245.c5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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