Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Contribution of cytosolic cysteine residues to the gating properties of the Kir2.1 inward rectifier.

Biophysical journal - 1 Jun 2003

Garneau L, Klein H, Parent L, Sauvé R

Abstract excerpt

The topological model proposed for the Kir2.1 inward rectifier predicts that seven of the channel 13 cysteine residues are distributed along the N- and C-terminus regions, with some of the residues comprised within highly conserved domains involved in channel gating. To determine if cytosolic cysteine residues contribute to the gating properties of Kir2.1, each of the N- and C-terminus cysteines was mutated into...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Membrane Permeability
Share to Cytosol
Share to Ion Channel Gating

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Membrane Potentials

Share to Porosity

Share to Potassium Channels, Inwardly Rectifying

Share to Static Electricity

Share to Xenopus laevis

Source

Open in PubMed Open full text

Identifiers

PMID: 12770878
DOI: 10.1016/S0006-3495(03)75100-5
PMCID: PMC1302954

Genes

PIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Contribution of cytosolic cysteine residues to the gating properties of the Kir2.1 inward rectifier.PMID 12770878Read ↗

Two critical cysteine residues implicated in disulfide bond formation and proper folding of Kir2.1.Semantic proximity Read ↗

Conformational changes at cytoplasmic intersubunit interactions control Kir channel gating.Semantic proximity Read ↗

Charges in the cytoplasmic pore control intrinsic inward rectification and single-channel properties in Kir1.1 and Kir2.1 channels.Semantic proximity Read ↗

KirBac1.1: it's an inward rectifying potassium channel.Semantic proximity Read ↗

Distant cytosolic residues mediate a two-way molecular switch that controls the modulation of inwardly rectifying potassium (Kir) channels by cholesterol and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)).Semantic proximity Read ↗

The role of the cytoplasmic pore in inward rectification of Kir2.1 channels.Semantic proximity Read ↗

Extracellular Kir2.1C122Y Mutant Upsets Kir2.1-PIP2 Bonds and Is Arrhythmogenic in Andersen-Tawil Syndrome.Semantic proximity Read ↗

State Dependent Anionic Pore Currents Conducted by Single Countercharge Mutants in a Voltage-Sensing PhosphataseSemantic proximity Read ↗

Two arginines in the cytoplasmic C-terminal domain are essential for voltage-dependent regulation of A-type K+ current in the Kv4 channel subfamily.Semantic proximity Read ↗

Effect of charge substitutions at residue his-142 on voltage gating of connexin43 channels.Semantic proximity Read ↗

A conserved threonine in the S1-S2 loop of KV7.2 and K V7.3 channels regulates voltage-dependent activation.Semantic proximity Read ↗

Novel insights into the structural basis of pH-sensitivity in inward rectifier K+ channels Kir2.3.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.