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Article

Loss of electrical communication, but not plaque formation, after mutations in the cytoplasmic loop of connexin43.

Heart rhythm - 1 Jul 2004

Seki Akiko, Coombs Wanda, Taffet Steven M, Delmar Mario

Abstract excerpt

OBJECTIVES: The aim of this study was to determine if the structural integrity of a region in the cytoplasmic loop (amino acids 119-144; region "L2") of connexin43 (Cx43) is necessary to maintain normal channel function. BACKGROUND: Cx43 is the most abundant gap junction protein in the heart. The ability of these channels to close under pathologic conditions such as ischemia may be a key substrate for cardiac...

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Identifiers

PMID: 15851157
DOI: 10.1016/j.hrthm.2004.03.066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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