Article
A new mechanism for prolactin processing into 16K PRL by secreted cathepsin D.
Molecular endocrinology (Baltimore, Md.) - 1 Dec 2006
Piwnica David, Fernandez Isabelle, Binart Nadine, Touraine Philippe, Kelly Paul A, Goffin Vincent
Abstract excerpt
Cathepsins are lysosomal enzymes that were shown to release the antiangiogenic fragments 16K prolactin (PRL), endostatin, and angiostatin by processing precursors at acidic pH in vitro. However, the physiological relevance of these findings is questionable because the neutral pH of physiological fluids is not compatible with the acidic conditions required for the proteolytic activity of these enzymes. Here we...
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