Article

Vasoinhibin is Generated by the Renin-Angiotensin System

2024-12-09

Abstract excerpt

<h4>ABSTRACT</h4> Vasoinhibin is a fragment of the hormone prolactin (PRL) that inhibits angiogenesis, vasopermeability, and vasodilation. Cathepsin D (CTSD) cleaves the N-teminal of PRL to generate vasoinhibin in the retina of neonate mice as revealed by the CTSD inhibitor, pepstatin A (PA). However, PA also inhibits renin. Because renin is expressed in the retina and the renin-angiotensin system (RAS) gives ris...

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Literature Corpus work: eef8b0f4-c1b9-53d7-b3d9-9bd9d9dda93c
DOI: 10.1101/2024.12.04.626908

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