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Article

Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S.

Pflugers Archiv : European journal of physiology - 1 Oct 2012

Haerteis Silke, Krappitz Matteus, Bertog Marko, Krappitz Annabel, Baraznenok Vera, Henderson Ian, Lindström Erik, Murphy Jane E, Bunnett Nigel W, Korbmacher Christoph

Abstract excerpt

Proteolytic processing of the amiloride-sensitive epithelial sodium channel (ENaC) by serine proteases is known to be important for channel activation. Inappropriate ENaC activation by proteases may contribute to the pathophysiology of cystic fibrosis and could be involved in sodium retention and the pathogenesis of arterial hypertension in the context of renal disease. We hypothesized that in addition to serine...

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Source

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Identifiers

PMID: 22864553
DOI: 10.1007/s00424-012-1138-3
PMCID: PMC3448907

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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