Article
The malignant phenotype and cysteine proteinases.
Biomedica biochimica acta - 1 Jan 1991
Sloane B F, Rozhin J, Krepela E, Ziegler G, Sameni M
Abstract excerpt
Expression, membrane association and secretion of both cathepsin B and cathepsin L have been associated with the malignant phenotype of murine B16 melanomas. Only native forms of the two enzymes were found in the lysosomal fractions, whereas both native and latent forms were found in the membrane fractions. Brief exposure to acid pH induced secretion of only native forms of both cathepsin B and cathepsin L and a...
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