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Article

Elucidating the function of secreted maspin: inhibiting cathepsin D-mediated matrix degradation.

Cancer research - 15 Apr 2007

Khalkhali-Ellis Zhila, Hendrix Mary J C

Abstract excerpt

Cellular interaction with the extracellular milieu plays a significant role in normal biological and pathologic processes. Excessive degradation of basement membrane matrix by proteolytic enzymes is a hallmark of tumor invasion and metastasis, and aspartyl proteinase cathepsin D is implicated as a major contributor to this process. Maspin, a non-inhibitory serpin, plays an important role in mammary gland...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17440060
DOI: 10.1158/0008-5472.CAN-06-4767
PMCID: PMC3177104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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