Article
The antiangiogenic factor 16K human prolactin induces caspase-dependent apoptosis by a mechanism that requires activation of nuclear factor-kappaB.
Molecular endocrinology (Baltimore, Md.) - 1 Sept 2003
Tabruyn Sebastien P, Sorlet Catherine M, Rentier-Delrue Francoise, Bours Vincent, Weiner Richard I, Martial Joseph A, Struman Ingrid
Abstract excerpt
We have previously shown that the 16-kDa N-terminal fragment of human prolactin (16K hPRL) has antiangiogenic properties, including the ability to induce apoptosis in vascular endothelial cells. Here, we examined whether the nuclear factor-kappaB (NF-kappaB) signaling pathway was involved in mediating the apoptotic action of 16K hPRL in bovine adrenal cortex capillary endothelial cells. In a dose-dependent...
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