Article
Adipose tissue in offspring of Lepr(db/+) mice: early-life environment vs. genotype.
American journal of physiology. Endocrinology and metabolism - 1 Jan 2007
Lambin Suzan, van Bree Rita, Caluwaerts Silvia, Vercruysse Lisbeth, Vergote Ignace, Verhaeghe Johan
Abstract excerpt
Gravidas with obesity and diabetes ("diabesity") may transmit this syndrome to their children through genetic and nongenetic mechanisms. Here, we used the Lepr(db/+) diabese mouse to examine the magnitude of these transmission modes, focusing on adipose tissue (AT). We compared the following six groups: wild-type (+/+) offspring from +/+ or db/+ dams (different early life environment) and db/+ offspring from db/+...
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