Article
Absence of a gestational diabetes phenotype in the LepRdb/+ mouse is independent of control strain, diet, misty allele, or parity.
Scientific reports - 24 Mar 2017
Plows Jasmine F, Yu XinYang, Broadhurst Ric, Vickers Mark H, Tong Chao, Zhang Hua, Qi HongBo, Stanley Joanna L, Baker Philip N
Abstract excerpt
Treatment options for gestational diabetes (GDM) are limited. In order to better understand mechanisms and improve treatments, appropriate animal models of GDM are crucial. Heterozygous db mice (db/+) present with glucose intolerance, insulin resistance, and increased weight gain during, but not prior to, pregnancy. This makes them an ideal model for GDM. However, several recent studies have reported an absence...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.