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Article

Parental diabetes: the Akita mouse as a model of the effects of maternal and paternal hyperglycemia in wildtype offspring.

PloS one - 1 Jan 2012

Grasemann Corinna, Devlin Maureen J, Rzeczkowska Paulina A, Herrmann Ralf, Horsthemke Bernhard, Hauffa Berthold P, Grynpas Marc, Alm Christina, Bouxsein Mary L, Palmert Mark R

Abstract excerpt

AIM/HYPOTHESIS: Maternal diabetes and high-fat feeding during pregnancy have been linked to later life outcomes in offspring. To investigate the effects of both maternal and paternal hyperglycemia on offspring phenotypes, we utilized an autosomal dominant mouse model of diabetes (hypoinsulinemic hyperglycemia in Akita mice). We determined metabolic and skeletal phenotypes in wildtype offspring of Akita mothers...

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Identifiers

PMID: 23209676
DOI: 10.1371/journal.pone.0050210
PMCID: PMC3509145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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