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Article

Maternal High-Fat Diet Alters Fetal Autonomic Activity Independently of Leptin Receptor Genotype in High-Risk Mouse Models of Type 2 Diabetes Mellitus.

The Journal of nutrition - 1 Dec 2025

Kasahara Yoshiyuki, Yoshida Chihiro, Kimura Yoshitaka, Saito Masatoshi

Abstract excerpt

BACKGROUND: The Developmental Origin of Health and Disease (DOHaD) concept suggests fetal environmental factors influence disease vulnerability later in life. Type 2 diabetes mellitus (T2DM), a metabolic disease, is associated with autonomic dysfunction. Some T2DM pathophysiological manifestations may exhibit DOHaD features and these autonomic changes could originate during fetal development. OBJECTIVES: This...

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PMID: 41076075
DOI: 10.1016/j.tjnut.2025.10.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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