Article
HIV1 cytopathogenicity-genetic difference between direct cytotoxic and fusogenic effect.
Virology - 1 Feb 1992
Hirsch I, Salaun D, Brichacek B, Chermann J C
Abstract excerpt
Formation of large syncytia, rapid cell killing, and early onset of replication are characteristics of the highly cytopathic Zairian virus strain HIV1 NDK compared with the HIV1 LAV prototype. Recombinant provirus molecules derived from cloned infectious DNAs of HIV1 LAV and NDK were constructed...
Topics
- Cell Death
- Cell Line
- Chimera
- Cytopathogenic Effect, Viral
- DNA, Recombinant
- DNA, Viral
- Genes, gag
- Genes, pol
- Giant Cells
- HIV-1
- Humans
- Phenotype
- Virus Replication