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Article

HIV1 cytopathogenicity-genetic difference between direct cytotoxic and fusogenic effect.

Virology - 1 Feb 1992

Hirsch I, Salaun D, Brichacek B, Chermann J C

Abstract excerpt

Formation of large syncytia, rapid cell killing, and early onset of replication are characteristics of the highly cytopathic Zairian virus strain HIV1 NDK compared with the HIV1 LAV prototype. Recombinant provirus molecules derived from cloned infectious DNAs of HIV1 LAV and NDK were constructed by reciprocal exchange of genetic material using conserved restriction sites. Different regions of the HIV1 genome were...

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PMID: 1733106
DOI: 10.1016/0042-6822(92)90031-j

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