Article
Cytopathic killing of peripheral blood CD4(+) T lymphocytes by human immunodeficiency virus type 1 appears necrotic rather than apoptotic and does not require env.
Journal of virology - 1 May 2002
Lenardo Michael J, Angleman Sara B, Bounkeua Viengngeun, Dimas Joseph, Duvall Melody G, Graubard Moses B, Hornung Felicita, Selkirk Marianne C, Speirs Christina K, Trageser Carol, Orenstein Jan O, Bolton Diane L
Abstract excerpt
An important unresolved issue of AIDS pathogenesis is the mechanism of human immunodeficiency virus (HIV)-induced CD4(+) T-lymphocyte destruction. We show here that HIV type 1 (HIV-1) exerts a profound cytopathic effect upon peripheral blood CD4(+) T lymphocytes that resembles necrosis rather than apoptosis. Necrotic cytopathology was found with both laboratory-adapted strains and primary isolates of HIV-1. We...
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