Attenuation of human immunodeficiency virus type 1 cytopathic effect by a mutation affecting the transmembrane envelope glycoprotein.

doi:10.1128/JVI.65.1.281-291.1991

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Article

Attenuation of human immunodeficiency virus type 1 cytopathic effect by a mutation affecting the transmembrane envelope glycoprotein.

Journal of virology - 1 Jan 1991

Kowalski M, Bergeron L, Dorfman T, Haseltine W, Sodroski J

Abstract excerpt

The cytopathic effects of human immunodeficiency virus type 1 (HIV-1) infection are specific for cells that express the CD4 viral receptor and consist of syncytium formation and single-cell lysis. Here we report that a mutation (517A) affecting the amino terminus of the HIV-1 gp41 transmembrane envelope glycoprotein resulted in a virus that was markedly less cytopathic than was wild-type HIV-1. In systems in...

Topics

Amino Acid Sequence
Blotting, Southern
CD4 Antigens
Cell Line
Cell Transformation, Viral
Cells, Cultured
DNA, Viral
HIV Envelope Protein gp41
HIV-1
Humans
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukocytes, Mononuclear

Molecular Sequence Data

Mutation

Plasmids

RNA-Directed DNA Polymerase

Restriction Mapping

T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 1702159
DOI: 10.1128/JVI.65.1.281-291.1991
PMCID: PMC240515

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1702159-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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