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Article

Attenuation of human immunodeficiency virus type 1 cytopathic effect by a mutation affecting the transmembrane envelope glycoprotein.

Journal of virology - 1 Jan 1991

Kowalski M, Bergeron L, Dorfman T, Haseltine W, Sodroski J

Abstract excerpt

The cytopathic effects of human immunodeficiency virus type 1 (HIV-1) infection are specific for cells that express the CD4 viral receptor and consist of syncytium formation and single-cell lysis. Here we report that a mutation (517A) affecting the amino terminus of the HIV-1 gp41 transmembrane envelope glycoprotein resulted in a virus that was markedly less cytopathic than was wild-type HIV-1. In systems in...

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Identifiers

PMID: 1702159
DOI: 10.1128/JVI.65.1.281-291.1991
PMCID: PMC240515

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