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Article

Molecular determinants of acute single-cell lysis by human immunodeficiency virus type 1.

Journal of virology - 1 Mar 1996

Cao J, Park I W, Cooper A, Sodroski J

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) infection of CD4-positive lymphocytes is accompanied by acute cytopathic effects, i.e., syncytium formation and single-cell lysis. Syncytium formation involves cell-cell fusion mediated by viral envelope glycoproteins on the surface of infected cells an...

Topics

CD4-Positive T-Lymphocytes
Cell Line
Cytopathogenic Effect, Viral
Gene Expression
Gene Products, env
HIV Envelope Protein gp120
HIV Envelope Protein gp160
HIV Envelope Protein gp41
HIV-1
Humans
Membrane Glycoproteins
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Precursors

Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 8627650
DOI: 10.1128/JVI.70.3.1340-1354.1996
PMCID: PMC189953

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8627650-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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