Article
Selective ablation of matrix metalloproteinase-2 exacerbates experimental colitis: contrasting role of gelatinases in the pathogenesis of colitis.
Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2006
Garg Pallavi, Rojas Mauricio, Ravi Anupama, Bockbrader Katrina, Epstein Steven, Vijay-Kumar Matam, Gewirtz Andrew T, Merlin Didier, Sitaraman Shanthi V
Abstract excerpt
The matrix metalloproteinases (MMPs), MMP-2 and MMP-9, share structural and substrate similarities and are up-regulated during human as well as animal models of inflammatory bowel disease. We recently demonstrated that epithelial-derived MMP-9 is an important mediator of inflammation and tissue damage in colitis. In this study, we examined the role of MMP-2 in acute colitis. Colitis was induced using two models,...
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