Article
Deficiency of Protein Tyrosine Phosphatase Non-Receptor Type 2 in Intestinal Epithelial Cells Has No Appreciable Impact on Dextran Sulphate Sodium Colitis Severity But Promotes Wound Healing.
Digestion - 1 Jan 2016
Kasper Stephanie H, Spalinger Marianne R, Leonardi Irina, Gerstgrasser Alexandra, Raselli Tina, Gottier Claudia, Atrott Kirstin, Frey-Wagner Isabelle, Fischbeck-Terhalle Anne, Rogler Gerhard, Scharl Michael
Abstract excerpt
BACKGROUND/AIMS: The protein tyrosine phosphatase non-receptor type 2 (PTPN2) is known to mediate susceptibility to inflammatory bowel diseases. Cell culture experiments suggest that PTPN2 influences barrier function, autophagy and secretion of pro-inflammatory cytokines. PTPN2 knockout mice die a few weeks after birth due to systemic inflammation, emphasizing the importance of this phosphatase in inflammatory...
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