Article
Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice.
Cell - 22 Oct 1993
Mombaerts P, Mizoguchi E, Grusby M J, Glimcher L H, Bhan A K, Tonegawa S
Abstract excerpt
We describe the spontaneous development of inflammatory bowel disease (IBD) in several immunodeficient mouse strains created via gene targeting in embryonic stem cells. Chronic colitis was observed in T cell receptor (TCR) alpha mutant, TCR beta mutant, TCR beta x delta double mutant, or class II...
Topics
- Aging
- Animals
- B-Lymphocytes
- CD4-Positive T-Lymphocytes
- Colitis, Ulcerative
- Disease Models, Animal
- Genes, MHC Class II
- Homeodomain Proteins
- Inflammatory Bowel Diseases
- Intestinal Mucosa
- Lymphocyte Subsets
- Mice
- Mice, Mutant Strains
- Mice, Nude
- Mutation
- Proteins
- Receptors, Antigen, T-Cell
- Receptors, Antigen, T-Cell, alpha-beta