Article
Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8).
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2007
Gutiérrez-Fernández Ana, Inada Masaki, Balbín Milagros, Fueyo Antonio, Pitiot Ana S, Astudillo Aurora, Hirose Kenji, Hirata Michiko, Shapiro Steven D, Noël Agnès, Werb Zena, Krane Stephen M, López-Otín Carlos, Puente Xose S
Abstract excerpt
Matrix metalloproteinases (MMPs) have been implicated in numerous tissue-remodeling processes. The finding that mice deficient in collagenase-2 (MMP-8) are more susceptible to develop skin cancer, prompted us to investigate the role of this protease in cutaneous wound healing. We have observed a significant delay in wound closure in MMP8-/- mice and an altered inflammatory response in their wounds, with a delay...
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