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Article

Exacerbated experimental colitis in TNFAIP8-deficient mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2015

Sun Honghong, Lou Yunwei, Porturas Thomas, Morrissey Samantha, Luo George, Qi Ji, Ruan Qingguo, Shi Songlin, Chen Youhai H

Abstract excerpt

The TNF-α-induced protein 8 (TNFAIP8 or TIPE) is a risk factor for cancer and bacterial infection, and its expression is upregulated in a number of human cancers. However, its physiologic and pathologic functions are unclear. In this study, we describe the generation of TIPE-deficient mice and their increased sensitivity to colonic inflammation. TIPE-deficient mice were generated by germ line gene targeting and...

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Identifiers

PMID: 25948814
DOI: 10.4049/jimmunol.1401986
PMCID: PMC4458398

Genes

TNFAIP8
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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