Article
Evolution of the V, D, and J gene segments used in the primate gammadelta T-cell receptor reveals a dichotomy of conservation and diversity.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 2011
Kazen Allison R, Adams Erin J
Abstract excerpt
γδ T cells are an immunological enigma in that both their function in the immune response and the molecular mechanisms behind their activation remain unclear. These cells predominate in the epithelia and can be rapidly activated to provide an array of responses. However, no homologous γδ T-cell populations have been identified between humans and mice, and our understanding of what these cells recognize as ligands...
Topics
- Animals
- Base Sequence
- Cluster Analysis
- Computational Biology
- Conserved Sequence
- DNA Primers
- Evolution, Molecular
- Genes, Immunoglobulin Heavy Chain
- Genetic Variation
- Humans
- Mice
- Molecular Sequence Data
- Phylogeny
- Primates