Identification of the region of T cell receptor beta chain that interacts with the self-superantigen MIs-1a.

doi:10.1016/0092-8674(90)90700-o

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Article

Identification of the region of T cell receptor beta chain that interacts with the self-superantigen MIs-1a.

Cell - 29 Jun 1990

Pullen A M, Wade T, Marrack P, Kappler J W

Abstract excerpt

Superantigen-MHC complexes are known to stimulate T cells primarily via the V beta element of the T cell receptor. In this paper we identify a number of amino acid residues that define the region of a particular V beta element interacting with one of the self-superantigens, MIs-1a. These residues are predicted to lie on a beta-pleated sheet of the T cell receptor, away from the complementarity determining regions...

Topics

Animals
Antigens, Surface
Cloning, Molecular
Epitopes
Gene Expression
Genetic Variation
Macromolecular Substances
Major Histocompatibility Complex
Membrane Glycoproteins
Mice
Mice, Inbred Strains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Minor Lymphocyte Stimulatory Antigens

Models, Molecular

Mutation

Plasmids

Polymerase Chain Reaction

Protein Conformation

Receptors, Antigen, T-Cell

Source

Open in PubMed

Identifiers

PMID: 1694725
DOI: 10.1016/0092-8674(90)90700-o

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1694725-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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