Article
Identification of the region of T cell receptor beta chain that interacts with the self-superantigen MIs-1a.
Cell - 29 Jun 1990
Pullen A M, Wade T, Marrack P, Kappler J W
Abstract excerpt
Superantigen-MHC complexes are known to stimulate T cells primarily via the V beta element of the T cell receptor. In this paper we identify a number of amino acid residues that define the region of a particular V beta element interacting with one of the self-superantigens, MIs-1a. These residues are predicted to lie on a beta-pleated sheet of the T cell receptor, away from the complementarity determining regions...
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