Article
Subsets of HLA-DR1 molecules defined by SEB and TSST-1 binding.
Science (New York, N.Y.) - 16 Dec 1994
Thibodeau J, Cloutier I, Lavoie P M, Labrecque N, Mourad W, Jardetzky T, Sékaly R P
Abstract excerpt
Superantigens bind to major histocompatibility complex class II molecules on antigen-presenting cells and stimulate T cells. Staphylococcus aureus enterotoxin B (SEB) and toxic shock syndrome toxin-1 (TSST-1) bind to the same region of human lymphocyte antigen (HLA)-DR1 but do not compete with ea...
Topics
- Animals
- Antigen Presentation
- Bacterial Toxins
- Binding Sites
- Binding, Competitive
- Cell Line
- Enterotoxins
- HLA-DR1 Antigen
- HeLa Cells
- Humans
- Hybridomas
- Mice
- Mutation
- Protein Structure, Secondary
- Staphylococcus aureus
- Superantigens
- T-Lymphocytes