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Article

Subsets of HLA-DR1 molecules defined by SEB and TSST-1 binding.

Science (New York, N.Y.) - 16 Dec 1994

Thibodeau J, Cloutier I, Lavoie P M, Labrecque N, Mourad W, Jardetzky T, Sékaly R P

Abstract excerpt

Superantigens bind to major histocompatibility complex class II molecules on antigen-presenting cells and stimulate T cells. Staphylococcus aureus enterotoxin B (SEB) and toxic shock syndrome toxin-1 (TSST-1) bind to the same region of human lymphocyte antigen (HLA)-DR1 but do not compete with each other, which indicates that they bind to different subsets of DR1 molecules. Here, a mutation in the peptide-binding...

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Identifiers

PMID: 7997881
DOI: 10.1126/science.7997881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Subsets of HLA-DR1 molecules defined by SEB and TSST-1 binding.PMID 7997881Read ↗

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Toxic Shock Syndrome and Bacterial Superantigens: An UpdateSemantic proximity Read ↗

The superantigens SpeC and TSST-1 specifically activate TRBV12-3/12-4+ memory T cellsSemantic proximity Read ↗

HLA Class II Polymorphisms Determine Responses to Bacterial SuperantigensSemantic proximity Read ↗

Defining a novel domain of staphylococcal toxic shock syndrome toxin-1 critical for major histocompatibility complex class II binding, superantigenic activity, and lethalitySemantic proximity Read ↗

Human Skin T Cells Express Conserved T-Cell Receptors that Cross-React with Staphylococcal Superantigens and CD1aSemantic proximity Read ↗

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