Article
The V beta complementarity determining region 1 of a major histocompatibility complex (MHC) class I-restricted T cell receptor is involved in the recognition of peptide/MHC I and superantigen/MHC II complex.
The Journal of experimental medicine - 1 Apr 1994
Bellio M, Lone Y C, de la Calle-Martin O, Malissen B, Abastado J P, Kourilsky P
Abstract excerpt
We investigated the role of the complementarity determining region 1 (CDR1) of T cell receptor (TCR) beta chain both in antigen/major histocompatibility complex I (MHC I) and in superantigen (SAg)/MHC II complex recognition. Residues 26 to 31 of the V beta 10 domain of a TCR derived from an H-2Kd...
Topics
- Alanine
- Alleles
- Amino Acid Sequence
- Animals
- Cell Line
- H-2 Antigens
- Histocompatibility Antigens Class II
- Hybridomas
- L Cells
- Mice
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Peptides
- Receptors, Antigen, T-Cell, alpha-beta