Article
Molecular characterization of the putative T-cell receptor cavity of the superantigen staphylococcal enterotoxin B.
Immunology - 1 Jun 1998
Garcia C, Briggs C, Zhang L, Guan L, Gabriel J L, Rogers T J
Abstract excerpt
A number of investigators have utilized a variety of methods to identify the structural basis for the interaction of superantigens with the T-cell receptor beta-chain. The previous studies strongly suggest that a region of the toxin near residues N23, Y61, Y91 and D209 is important for this bindi...
Topics
- Alleles
- Animals
- Cell Division
- Enterotoxins
- HLA-DR1 Antigen
- Mice
- Mice, Inbred C3H
- Mitogens
- Mutagenesis, Site-Directed
- Polymerase Chain Reaction
- Receptors, Antigen, T-Cell, alpha-beta
- Staphylococcus aureus
- Structure-Activity Relationship
- Superantigens