Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Toxic Shock Syndrome Toxin-1 Complexed with a Class II Major Histocompatibility Molecule HLA-DR1

16 Dec 1994

Abstract excerpt

The three-dimensional structure of a Staphylococcus aureus superantigen, toxic shock syndrome toxin-1 (TSST-1), complexed with a human class II major histocompatibility molecule (DR1), was determined by x-ray crystallography. The TSST-1 binding site on DR1 overlaps that of the superantigen S. aureus enterotoxin B (SEB), but the two binding modes differ. Whereas SEB binds primarily off one edge of the peptide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimicrobial Resistance in Staphylococcus
Share to Clostridium difficile and Clostridium perfringens research
Share to Toxin Mechanisms and Immunotoxins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7997880
DOI: 10.1126/science.7997880

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Toxic Shock Syndrome Toxin-1 Complexed with a Class II Major Histocompatibility Molecule HLA-DR1PMID 7997880Read ↗

Structure of toxic shock syndrome toxin 1.Semantic proximity Read ↗

Subsets of HLA-DR1 molecules defined by SEB and TSST-1 binding.Semantic proximity Read ↗

Identification of class II major histocompatibility complex and T cell receptor binding sites in the superantigen toxic shock syndrome toxin 1.Semantic proximity Read ↗

Defining a novel domain of staphylococcal toxic shock syndrome toxin-1 critical for major histocompatibility complex class II binding, superantigenic activity, and lethalitySemantic proximity Read ↗

Toxic Shock Syndrome and Bacterial Superantigens: An UpdateSemantic proximity Read ↗

Staphylococcal enterotoxin A has two cooperative binding sites on major histocompatibility complex class II.Semantic proximity Read ↗

Structures of five mutants of toxic shock syndrome toxin-1 with reduced biological activity.Semantic proximity Read ↗

Analysis of superantigenic toxin Vβ T-cell signatures produced during cases of staphylococcal toxic shock syndrome and septic shockSemantic proximity Read ↗

Staphylococcal enterotoxin A induces small clusters of HLA-DR1 on B cells.Semantic proximity Read ↗

Human scFvs That Counteract Bioactivities of Staphylococcus aureus TSST-1.Semantic proximity Read ↗

Inhibition of Staphylococcal Enterotoxin A–Induced Superantigenic and Lethal Activities by a Monoclonal Antibody to Toxic Shock Syndrome Toxin–1Semantic proximity Read ↗

Structural basis for abrogated binding between staphylococcal enterotoxin A superantigen vaccine and MHC-IIalpha.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.