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Article

T cell receptor interaction with peptide/major histocompatibility complex (MHC) and superantigen/MHC ligands is dominated by antigen.

The Journal of experimental medicine - 1 Aug 1993

Ehrich E W, Devaux B, Rock E P, Jorgensen J L, Davis M M, Chien Y H

Abstract excerpt

While recent evidence strongly suggests that the third complementarity determining regions (CDR3s) of T cell receptors (TCRs) directly contact antigenic peptides bound to major histocompatibility complex (MHC) molecules, the nature of other TCR contact(s) is less clear. Here we probe the extent to which different antigens can affect this interaction by comparing the responses of T cells bearing structurally...

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PMID: 8393480
DOI: 10.1084/jem.178.2.713
PMCID: PMC2191102

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