Article
Superantigens interact with MHC class II molecules outside of the antigen groove.
Cell - 21 Sept 1990
Dellabona P, Peccoud J, Kappler J, Marrack P, Benoist C, Mathis D
Abstract excerpt
Superantigens, including the staphylococcal enterotoxins and the minor lymphocyte stimulatory antigens, are highly potent immunostimulatory molecules, capable of activating virtually all T cells that express particular T cell receptor (TCR) variable regions. Superantigen stimulation of T lymphocy...
Topics
- Amino Acid Sequence
- Animals
- Antigen-Presenting Cells
- Antigens
- Binding Sites
- Binding, Competitive
- Cell Line
- Histocompatibility Antigens Class II
- Hybridomas
- Mice
- Mice, Inbred CBA
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Conformation
- T-Lymphocytes
- Transfection