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Article

Superantigens interact with MHC class II molecules outside of the antigen groove.

Cell - 21 Sept 1990

Dellabona P, Peccoud J, Kappler J, Marrack P, Benoist C, Mathis D

Abstract excerpt

Superantigens, including the staphylococcal enterotoxins and the minor lymphocyte stimulatory antigens, are highly potent immunostimulatory molecules, capable of activating virtually all T cells that express particular T cell receptor (TCR) variable regions. Superantigen stimulation of T lymphocytes depends on major histocompatibility complex (MHC) class II molecules, so there has been some debate as to whether...

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PMID: 2401011
DOI: 10.1016/0092-8674(90)90388-u

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